Use of rituximab and risk of re-hospitalization for children with neuromyelitis optica spectrum disorder

Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder

OBJECTIVE To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing. METHODS Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categoriz...

Tumefactive Brain Lesions in Patients with Neuromyelitis Optica Spectrum Disorder

Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis.  Clinical P...

Neuromyelitis Optica Spectrum Disorder Presenting with Pseudoathetosis

Dear Editor, Pseudoathetosis is a movement disorder that is characterized by involuntary, slow, and writhing movements. It can develop from lesions at all levels of proprioceptive sensory pathways, including the posterior column of the spinal cord, parietal cortex, thalamus, and peripheral nerves.1,2 Various conditions that involve the posterior column have been reported to cause spinal pseudoa...

Three cases of neuromyelitis optica spectrum disorder

Neuromyelitis optica (NMO) is characterized by attacks of optic neuritis and longitudinally extensive transverse myelitis. Cases positive for aquaporin 4 antibodies are classified to NMO spectrum disorder (NMOSD) which includes cases with optic neuritis, transverse myelitis, or with brain lesions typical of NMO. Our three cases with NMO/NMOSD revealed five imaging features: (i) extensive transv...

Efficacy and Safety of Rituximab in patients with Neuromyelitis Optica Spectrum Disorders: A prospective observation in Iranian Cases.